Experimental studies in rodents
Subject of our animal studies is the role of the endogenous cannabinoid system and the cerebral energy metabolism as well as their interaction in models for aspects of schizophrenic psychoses. In our translational research approach disorders of social behavior, cognition and motion of rats are experimentally induced in various ways. It is then possible to register relevant changes in behavior as well as its effect on the endogenous cannabinoid system and the cerebral energy metabolism. We are doing that with various invasive and non-invasive examination techniques. Examples are the animal PET or the examination of the concentration of endogenous cannabinoids in body fluids of the rats. Furthermore influences of established and recent pharmacotherapeutic interventions can be examined more detailed.
C. Rohleder, D. Wiedermann, B. Neumaier, A. Drzezga, L. Timmermann, R. Graf, F. M. Leweke, Heike Endepols: The functional networks of prepulse inhibition: Neuronal connectivity analysis based on FDG-PET in awake and unrestrained rats. Front Behav Neurosci (2016) 10:148.
C. Rohleder, F. Jung, H. Mertgens, D. Wiedermann, M. Sue, B. Neumaier, R. Graf, F. M. Leweke, H. Endepols: Functional metabolic PET-imaging of auditory prepulse inhibition in awake rats. Front Behav Neurosci (2014) epub ahead.
F. M. Leweke, M. Schneider: Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine. Int J Neuropsychopharmacol (2011) 14: 43-51.
M. Klugmann, V. Klippenstein, F. M. Leweke, R. Spanagel, M. Schneider: Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. Int J Neuropsychopharmacol (2011) 14: 505-517.
M. Schneider, E. Schömig, F. M. Leweke: Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats. Addict Biol (2008) 13: 345-357.
M. Schneider, E. Drews, M. Koch, E. Schömig, F. M. Leweke: Behavioral effects in adult rats of chronic treatment with the cannabinoid receptor agonist win 55,212-2 during different phases of development. Behav Pharmacol (2005) 16: S57-58.